Cat
The following database tables have been arranged into two categories: All Measurands, and Laboratory Applications. Clinical Applications will be addressed on the RCV Calculator page.
Measurands
Lists all measurands that have been assessed for that species.
Reference number relates to the citation list.
Legend:
CVI - intraindividual variation.
CVG- between individual variation.
CVA - analyser variation (reported in the study, shown in red if > 0.5 x CVI). This can be determined by replicate analyses or from quality control studies (QCM)
II - Index of Individuality. A high level indicates subject-based reference intervals (RCV) are more appropriate, a low level indicates population-based reference intervals are appropriate, intermediate levels indicate both reference change values and reference intervals should be assessed.
RCV - reference change value calculated to 95% and 99%.
These terms are explained on the ‘About BV’ page.
| Measurand | Sample Type | Reference | Health Status | Breed(s) | Subjects (n) Samples Frequency | CVI (%) (CI) | CVG (%) (CI) | CVA (%) (CI) Source | II | RCV (95%) RCV (99%) | Comments | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Albumin | Plasma (heparin) | 30 | Healthy | DSH | 14 | 3.0 | 3.9 | 2.0 | 1.1 | 9.9 | Siemens Advia 1800, Tukey's outlier test (3 exclusions),normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 13.1 | |||||||||
| weekly | ||||||||||||
| Albumin | Serum | 38 | Healthy | 5 x DSH | 7 | 2.7 | 9.5 | 2.9 | 2.4 | 11.0 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 14.5 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Albumin | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 3.2 | 5.9 | 1.4 | 1.7 | 9.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | High | 12.7 | |||||||||
| various | ||||||||||||
| Albumin | Serum | 66 | Healthy | 10 x DSH | 15 | 3.6 | 7.6 | 1.2 | 2.0 | 10.4 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (3.2-4.0) | (7.0-8.5) | (1.1-1.3) | High | 13.8 | ||||||
| 8-weekly | duplicate | |||||||||||
| Alkaline phosphatase (ALP) | Plasma (heparin) | 30 | Healthy | DSH | 14 | 12.5 | 33.7 | 4.6 | 2.5 | 36.8 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot | |
| 6 | duplicate | High | 48.5 | |||||||||
| weekly | ||||||||||||
| Alkaline phosphatase (ALP) | Serum | 38 | Healthy | 5 x DSH | 7 | 8.6 | 36.2 | 4.2 | 3.8 | 26.5 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 34.9 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Alkaline phosphatase (ALP) | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 10.2 | 27.8 | 1.6 | 2.7 | 28.6 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | High | 37.7 | |||||||||
| various | ||||||||||||
| Alkaline phosphatase (ALP) | Serum | 66 | Healthy | 10 x DSH | 15 | 18.1 | 31.6 | 2.3 | 1.7 | 79.1 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | duplicate | High | 126.4 | ||||||||
| 8-weekly | ||||||||||||
| Alanine aminotransferase (ALT) | Plasma (heparin) | 30 | Healthy | DSH | 14 | 13.2 | 23.0 | 3.8 | 1.7 | 39.5 65.3 | Siemens Advia 1800, Tukey's outlier test, normal distribution after log transformation, hence RCV varies for decreasing (above) or increasing (below) values. | |
| 6 | duplicate | High | 48.4 93.8 | |||||||||
| weekly | ||||||||||||
| Alanine aminotransferase (ALT) | Serum | 38 | Healthy | 5 x DSH, | 7 | 8.0 | 30.0 | 2.9 | 3.5 | 23.6 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 31.0 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Alanine aminotransferase (ALT) | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 16.1 | 18.8 | 1.2 | 1.2 | 44.8 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 58.9 | |||||||||
| various | ||||||||||||
| Alanine aminotransferase (ALT) | Serum | 66 | Healthy | 10 x DSH | 15 | 15.3 | 15.1 | 1.8 | 1.0 | 94.9 105.4 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | duplicate | Intermediate | |||||||||
| 8-weekly | ||||||||||||
| Aspartate aminotransferase (AST) | Plasma (heparin) | 30 | Healthy | DSH | 14 | 14.7 | 15.0 | 3.7 | 1.0 | 41.9 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 55.2 | |||||||||
| weekly | ||||||||||||
| Aspartate aminotransferase (AST) | Serum | 38 | Healthy | 5 x DSH | 7 | 11.3 | 19.8 | 4.6 | 1.6 | 33.8 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Intermediate | 44.5 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Aspartate aminotransferase (AST) | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 19.1 | 16.7 | 1.4 | 0.9 | 53.1 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 69.9 | |||||||||
| various | ||||||||||||
| Aspartate aminotransferase (AST) | Serum | 66 | Healthy | 10 x DSH | 15 | 16.2 | 19.2 | 3.2 | 1.2 | 90.5 110.5 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | duplicate | Intermediate | |||||||||
| 8-weekly | ||||||||||||
| Bile Acids | Serum | 38 | Healthy | 5 x DSH | 7 | 129.9 | 46.5 | 2.9 | 0.4 | 360.2 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 474.1 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Calcium | Plasma (heparin) | 30 | Healthy | DSH | 14 | 2.3 | 2.5 | 1.4 | 0.9 | 7.6 | Siemens Advia 1800, Tukey's outlier test (9 exclusions),normal distribution by residuals plot | |
| 6 | duplicate | Intermediate | 10.0 | |||||||||
| weekly | ||||||||||||
| Calcium | Serum | 38 | Healthy | 5 x DSH | 7 | 1.6 | 1.6 | 2.8 | 0.5 | 8.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 11.8 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Calcium | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 2.2 | 4.7 | 1.0 | 1.9 | 6.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | High | 8.8 | |||||||||
| various | ||||||||||||
| Calcium | Serum | 66 | Healthy | 10 x DSH | 15 | 2.5 | 4.1 | 0.7 | 1.6 | 7.2 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (2.3-2.8) | (3.7-4.5) | (0.7-0.8) | Intermediate | 9.5 | ||||||
| 8-weekly | duplicate | |||||||||||
| Carbon Dioxide/ Bicarbonate | Plasma (heparin) | 30 | Healthy | DSH | 14 | 5.4 | 9.6 | 5.2 | 1.3 | 20.7 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot | |
| 6 | duplicate | Intermediate | 27.3 | |||||||||
| weekly | ||||||||||||
| Carbon Dioxide/ Bicarbonate | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 8.1 | 9.7 | 4.7 | 1.0 | 26.0 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 34.2 | |||||||||
| various | ||||||||||||
| Carbon Dioxide/ Bicarbonate | Serum | 66 | Healthy | 10 x DSH | 15 | 10.1 | 4.1 | 2.6 | 0.4 | 28.9 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | (9.1-11.2) | (3.7-4.5) | (2.3-2.9) | Low | 38.1 | ||||||
| 8-weekly | duplicate | |||||||||||
| Chloride | Plasma (heparin) | 30 | Healthy | DSH | 14 | 1.2 | 1.2 | 1.0 | 0.8 | 4.2 | Siemens Advia 1800, Tukey's outlier test (9 exclusions),normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 5.5 | |||||||||
| weekly | ||||||||||||
| Chloride | Serum | 38 | Healthy | 5 x DSH, | 7 | 0.0 | 1.2 | 2.0 | 0.6 | 8.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 11.8 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Chloride | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 1.0 | 1.0 | 0.7 | 0.8 | 6.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 8.8 | |||||||||
| various | ||||||||||||
| Chloride | Serum | 66 | Healthy | 10 x DSH | 15 | 1.2 | 1.3 | 1.8 | 0.6 | 6.0 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (1.1-1.4) | (1.2-1.4) | (1.6-2.0) | Low | 7.9 | ||||||
| 8-weekly | duplicate | |||||||||||
| Cholesterol | Plasma (heparin) | 30 | Healthy | DSH | 14 | 10.7 | 22.4 | 3.4 | 2.0 | 31.2 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot | |
| 6 | duplicate | High | 41.1 | |||||||||
| weekly | ||||||||||||
| Cholesterol | Serum | 38 | Healthy | 5 x DSH, | 7 | 5.1 | 36.1 | 3.1 | 6.0 | 8.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 11.8 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Cholesterol | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 5.9 | 17.1 | 4.0 | 2.4 | 6.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | High | 8.8 | |||||||||
| various | ||||||||||||
| Cholesterol | Serum | 66 | Healthy | 10 x DSH | 15 | 15.5 | 22.7 | 0.9 | 1.5 | 28.9 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (14.0-17.1) | (20.1-24.7) | (0.8-1.0) | Intermediate | 56.6 | ||||||
| 8-weekly | duplicate | |||||||||||
| Creatine Kinase (CK) | Plasma (heparin) | 30 | Healthy | DSH | 14 | 31.0 | 34.0 | 3.1 | 1.1 | 39.3 512.5 | Siemens Advia 1800, Tukey's outlier test, normal distribution after log transformation, hence RCV varies for decreasing (above) or increasing (below) values. | |
| 6 | duplicate | Intermediate | 48.3 842.7 | |||||||||
| weekly | ||||||||||||
| Creatine Kinase (CK) | Serum | 38 | Healthy | 5 x DSH, | 7 | 27.4 | 36.8 | 2.9 | 1.3 | 76.4 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Intermediate | 100.5 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Creatine Kinase (CK) | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 51.7 | 47.3 | 3.1 | 0.9 | 143.6 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 189.0 | |||||||||
| various | ||||||||||||
| Creatine Kinase (CK) | Serum | 66 | Healthy | 10 x DSH | 15 | 29.2 | 55.6 | 1.1 | 1.9 | 53.5 187.3 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | duplicate | High | |||||||||
| 8-weekly | ||||||||||||
| Creatinine | Plasma (heparin) | 30 | Healthy | DSH | 14 | 6.0 | 11.4 | 1.9 | 1.8 | 17.4 | Siemens Advia 1800, Tukey's outlier test (2 exclusions),normal distribution by residuals plot. | |
| 6 | duplicate | High | 22.9 | |||||||||
| weekly | ||||||||||||
| Creatinine | Serum | 38 | Healthy | 5 x DSH | 7 | 10.2 | 32.5 | 2.2 | 3.1 | 28.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 38.1 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Creatinine | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 11.3 | 23.4 | 1.2 | 2.1 | 31.5 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | High | 41.5 | |||||||||
| various | ||||||||||||
| Creatinine | Serum | 66 | Healthy | 10 x DSH | 15 | 13.0 | 19.0 | 3.0 | 1.4 | 36.8 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (11.8-14.2) | (17.0-20.7) | (2.7-3.3) | Intermediate | 48.7 | ||||||
| 8-weekly | duplicate | |||||||||||
| γ glutamyl transferase (GGT) | Plasma (heparin) | 30 | Healthy | DSH | 14 | 0.0 | 0.0 | 0.0 | N/A | 0.0 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot | |
| 6 | duplicate | 0.0 | ||||||||||
| weekly | ||||||||||||
| Globulin | Plasma (heparin) | 30 | Healthy | DSH | 14 | 4.1 | 11.3 | 2.0 | 2.5 | 12.7 | Siemens Advia 1800, Tukey's outlier test (3 exclusions),normal distribution by residuals plot. | |
| 6 | duplicate | High | 16.8 | |||||||||
| weekly | ||||||||||||
| Globulin | Serum | 66 | Healthy | 10 x DSH | 15 | 7.1 | 12.1 | 1.5 | 1.9 | 20.1 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (6.4-7.9) | (10.9-13.4) | (1.3-1.6) | High | 26.5 | ||||||
| 8-weekly | duplicate | |||||||||||
| Glucose | Plasma (heparin) | 30 | Healthy | DSH | 14 | 6.8 | 8.1 | 2.6 | 1.1 | 16.9 20.5 | Siemens Advia 1800, Tukey's outlier test, normal distribution after log transformation, hence RCV varies for decreasing (above) or increasing (below) values. | |
| 6 | duplicate | Intermediate | 25.8 34.8 | |||||||||
| weekly | ||||||||||||
| Glucose | Serum | 38 | Healthy | 5 x DSH | 7 | 7.8 | 4.0 | 2.7 | 0.5 | 22.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 30.1 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Glucose | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 12.7 | 5.9 | 1.1 | 0.5 | 35.3 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Low | 46.5 | |||||||||
| various | ||||||||||||
| Glucose | Serum | 66 | Healthy | 10 x DSH | 15 | 19.3 | 17.4 | 1.4 | 0.9 | 53.7 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (17.3-21.0) | (15.7-19.0) | (1.3-1.6) | Intermediate | 70.6 | ||||||
| 8-weekly | duplicate | |||||||||||
| Iron | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 23.0 | 21.5 | 3.1 | 0.9 | 64.3 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 84.7 | |||||||||
| various | ||||||||||||
| Magnesium | Plasma (heparin) | 30 | Healthy | DSH | 14 | 3.7 | 4.0 | 4.0 | 0.7 | 15.2 | Siemens Advia 1800, Tukey's outlier test, normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 20.0 | |||||||||
| weekly | ||||||||||||
| Magnesium | Serum | 38 | Healthy | 5 x DSH, | 7 | 3.3 | 3.6 | 2.5 | 0.9 | 11.5 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Intermediate | 15.1 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Magnesium | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 5.1 | 6.3 | 1.4 | 1.2 | 14.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 19.3 | |||||||||
| various | ||||||||||||
| NT-pro-BNP | EDTA plasma | 42 | Healthy | 11x DSH | 12 | 13.1 | 14.6 | 6.2 | 1.0 | 40.2 | Cardiopet proBNP test. QCM determined from prior study. CVG not reported (calculated from reported CVI and II) | |
| 1 x Maine Coon | 6 | QCM | Intermediate | 19.3 | ||||||||
| 2 hourly | ||||||||||||
| NT-pro-BNP | EDTA plasma | 42 | Healthy | 11x DSH | 12 | 21.2 | 22.1 | 6.2 | 1.0 | 61.2 | 2nd generation canine QCM determined from prior study. CVG not reported (calculated from reported CVI and II) | |
| 1 x Maine Coon | 6 | QCM | Intermediate | 19.3 | ||||||||
| weekly | ||||||||||||
| Pancreatic Lipase | Serum | 46 | Healthy | DSH | 11 | 18.2 | 49.3 | 8.7 | 2.5 | 55.8 | Spec FPL assay. Results presented with and without subject with outlying CVI. Shown here without outlier. | |
| 4 | (14.1-24.5) | (7.2-11.0) | (33.7-87.5) | High | 73.5 | |||||||
| Fortnightly | duplicate | |||||||||||
| Phosphate | Plasma (heparin) | 30 | Healthy | DSH | 14 | 8.5 | 11.8 | 1.6 | 1.4 | 24.0 | Siemens Advia 1800, Tukey's outlier test (7 exclusions), | |
| 6 | duplicate | Intermediate | 31.6 | |||||||||
| weekly | ||||||||||||
| Phosphate | Serum | 38 | Healthy | 5 x DSH, | 7 | 6.1 | 11.1 | 2.4 | 1.7 | 18.2 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 23.9 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Phosphate | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 9.8 | 9.3 | 1.1 | 0.9 | 27.3 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 36.0 | |||||||||
| various | ||||||||||||
| Phosphate | Serum | 66 | Healthy | 10 x DSH | 15 | 10.2 | 7.2 | 2.0 | 0.7 | 28.7 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (9.2-11.2) | (6.5-7.9) | (1.8-2.2) | Low | 38.0 | ||||||
| 8-weekly | duplicate | |||||||||||
| Potassium | Plasma (heparin) | 30 | Healthy | DSH | 14 | 3.6 | 4.9 | 1.8 | 1.2 | 11.2 | Siemens Advia 1800, Tukey's outlier test (1 exclusion),normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 14.7 | |||||||||
| weekly | ||||||||||||
| Potassium | Serum | 38 | Healthy | 5 x DSH, | 7 | 5.2 | 3.5 | 1.8 | 0.6 | 15.3 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 20.1 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Potassium | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 6.8 | 5.3 | 1.1 | 0.8 | 19.1 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 25.1 | |||||||||
| various | ||||||||||||
| Potassium | Serum | 66 | Healthy | 10 x DSH | 15 | 5.5 | 4.3 | 2.0 | 0.7 | 16.3 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (5.0-6.1) | (3.9-4.8) | (1.9-2.3) | Low | 21.4 | ||||||
| 8-weekly | duplicate | |||||||||||
| Sodium | Plasma (heparin) | 30 | Healthy | DSH | 14 | 0.9 | 0.6 | 0.9 | 0.5 | 3.5 | Siemens Advia 1800, Tukey's outlier test (1 exclusion),normal distribution by residuals plot. | |
| 6 | duplicate | Low | 4.6 | |||||||||
| weekly | ||||||||||||
| Sodium | Serum | 38 | Healthy | 5 x DSH, | 7 | 0.0 | 0.8 | 1.9 | 0.4 | 5.3 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Low | 6.9 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Sodium | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 1.1 | 0.7 | 0.7 | 0.5 | 3.6 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Low | 4.8 | |||||||||
| various | ||||||||||||
| Sodium | Serum | 66 | Healthy | 10 x DSH | 15 | 1.4 | 0.6 | 1.7 | 0.3 | 6.1 | AU680 Beckman Coulter. Trend found in data and 'detrended' | |
| 5 x DLH | 7 | (1.3-1.5) | (0.6-0.7) | (1.6-1.9) | Low | 8.0 | ||||||
| 8-weekly | duplicate | |||||||||||
| Symmetric Dimethylarginine (SDMA) | Serum | 55 | Healthy | 9 x DSH | 10 | 19.1 | 24.8 | 3.4 | 1.3 | 53.7 | ||
| 1 x DLH | 6 | (16.7-21.6) | (21.4-28.3) | (3.0-3.9) | Intermediate | 70.7 | ||||||
| weekly | duplicate | |||||||||||
| Symmetric Dimethylarginine (SDMA) | Serum | 55 | Healthy | 9 x DSH | 10 | 19.9 | 24.8 | 10.0 | 1.1 | 61.7 | ||
| 1 x DLH | 6 | (17.1-23.0) | (21.1-28.3) | (8.7-11.7) | Intermediate | 81.2 | ||||||
| weekly | duplicate | |||||||||||
| Symmetric Dimethylarginine (SDMA) | Serum | 66 | Healthy | 10 x DSH | 15 | 16.0 | 12.3 | 5.7 | 0.7 | 47.2 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (14.5-17.6) | (11.1-13.5) | (5.2-6.3) | Low | 62.0 | ||||||
| 8-weekly | duplicate | |||||||||||
| Total bilirubin | Plasma (heparin) | 30 | Healthy | DSH | 14 | 87.5 | 94.3 | 39.8 | 1.0 | 83.8 518.5 | Siemens Advia 1800, Tukey's outlier test, normal distribution after log transformation, hence RCV varies for decreasing (above) or increasing (below) values. | |
| 7 | duplicate | Intermediate | 90.9 1000.6 | |||||||||
| weekly | ||||||||||||
| Total bilirubin | Serum | 66 | Healthy | 10 x DSH | 15 | 18.0 | 24.5 | 19.3 | 0.9 | 53.7 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (16.1-19.8) | (21.7-26.6) | (17.3-21.2) | Intermediate | 96.3 | ||||||
| 8-weekly | duplicate | |||||||||||
| Total protein | Plasma (heparin) | 30 | Healthy | DSH | 14 | 8.3 | 14.0 | 5.4 | 1.4 | 27.4 | Siemens Advia 1800, Tukey's outlier test (3 exclusions),normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 36.1 | |||||||||
| weekly | ||||||||||||
| Total protein | Serum | 38 | Healthy | 5 x DSH, | 7 | 3.5 | 9.3 | 2.5 | 2.2 | 11.9 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | High | 15.7 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Total protein | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 2.9 | 5.4 | 1.2 | 1.7 | 8.7 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 11.5 | |||||||||
| various | ||||||||||||
| Total protein | Serum | 66 | Healthy | 10 x DSH | 15 | 3.2 | 4.4 | 0.8 | 1.3 | 9.1 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (2.9-3.5) | (4.0-4.9) | (0.8-0.9) | Intermediate | 12.0 | ||||||
| 8-weekly | duplicate | |||||||||||
| Triglycerides | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 9.9 | 18.6 | 2.6 | 1.8 | 28.4 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 6 | QCM | High | 37.3 | |||||||||
| various | ||||||||||||
| Urea | Plasma (heparin) | 30 | Healthy | DSH | 14 | 10.4 | 15.5 | 1.9 | 1.5 | 29.4 | Siemens Advia 1800, Tukey's outlier test (1 exclusion),normal distribution by residuals plot. | |
| 6 | duplicate | Intermediate | 38.7 | |||||||||
| weekly | ||||||||||||
| Urea | Serum | 38 | Healthy | 5 x DSH, | 7 | 6.3 | 7.5 | 3.1 | 1.1 | 19.5 | Abbot Architect c4000, normal distribution by residuals histogram and QQ plots. | |
| 1x Balinese | 5 | duplicate | Intermediate | 25.6 | ||||||||
| 1x Bengal | weekly | |||||||||||
| Urea | Plasma (heparin) | 41 | Healthy | breed not specified | 14 | 11.3 | 14.6 | 1.9 | 1.3 | 31.8 | Ortho-Clinical Vitros 350, Sampling at days 1, 2, 7, 14, 31, 42, and 100. Normality by Q-Q plots. | |
| 7 | QCM | Intermediate | 41.8 | |||||||||
| various | ||||||||||||
| Urea | Serum | 66 | Healthy | 10 x DSH | 15 | 10.8 | 9.5 | 1.8 | 0.9 | 30.4 | AU680 Beckman Coulter | |
| 5 x DLH | 7 | (9.8-11.9) | (8.7-10.5) | (1.6-2.0) | Intermediate | 39.9 | ||||||
| 8-weekly | duplicate |
Haematology
Endocrinology
| Measurand | Sample Type | Reference | Health Status | Breed(s) | Subjects (n) Samples Frequency | CVI (%) (CI) | CVG (%) (CI) | CVA (%) (CI) Source | II | RCV (95%) RCV (99%) | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fructosamine | Serum | 38 | healthy | 5 x DSH, | 7 | 3.8 | 2.9 | 6.8 | 0.4 | 21.6 | Abbot Architect c4000 |
| 1x Balinese | 5 | duplicate | Low | 28.4 | normal distribution by residuals histogram and QQ plots. | ||||||
| 1x Bengal | weekly | 1 outlier cat excluded. | |||||||||
| HOMA-IR | Serum | 57 | Healthy | Not specified | 5 | 38.2 | 51 | 7.4 | 1.3 | 35 284 | Mercodia feline insulin ELISA. Skewed distributions log-transformed so RCV varies for decreases and increases. |
| homeostasis model | lean (n=5) only | 5 | (22.1-50.2) | (0-90.1) | (5.8-10.3) | ||||||
| insulin (mU/L) and glucose (mmol/L) divided by 22.5 to assess insulin resistance | weekly | duplicate | Intermediate | ||||||||
| HOMA-IR | Serum | 57 | Healthy | Not specified | 7 | 51 | 52.3 | 7.4 | 1 | 27 364 | Mercodia feline insulin ELISA. Skewed distributions log-transformed so RCV varies for decreases and increases. |
| homeostasis model | lean (n=5), | 5 | (33.4-65.4) | (0-87.7) | (5.9-9.7) | ||||||
| insulin (mU/L) and glucose (mmol/L) divided by 22.5 to assess insulin resistance | overweight (n=2) | weekly | duplicate | Intermediate | |||||||
| Insulin | Serum | 37 | healthy | Not specified | 5 | 58 | 34.1 | Not reported | - | Mercodia feline insulin ELISA. | |
| 5 | duplicate | - | CVA not reported thus II and RCV not calculated. | ||||||||
| weekly | |||||||||||
| Insulin | Serum | 57 | Healthy | Not specified | 5 | 38 | 52.1 | 6.6 | 1.4 | 36 281 | Mercodia feline insulin ELISA. Skewed distributions log-transformed so RCV varies for decreases and increases |
| lean (n=5) only | 5 | (22.1-49.9) | (0-92.1) | (5.2-9.2) | |||||||
| weekly | duplicate | Intermediate | |||||||||
| Insulin | Serum | 57 | Healthy | Not specified | 7 | 48.7 | 54.4 | 6.6 | 1.1 | 27 364 | Mercodia feline insulin ELISA. Skewed distributions log-transformed so RCV varies for decreases and increases |
| lean (n=5), | 5 | (32.1-62.3) | (0-91.2) | (5.3-8.6) | |||||||
| overweight (n=2) | weekly | duplicate | Intermediate | ||||||||
| Insulin-like growth factor I (IGF-I) | Serum | 36 | healthy | Not specified | 7 | 7.4 | 64.1 | 1.5 | 8.5 | 20.9 | Mediagnost E20 IGF-I ELISA. One replicate at the 3rd sampling was considered an outlier in one cat, and samples from all cats for that occasion. |
| 5 | duplicate | High | 27.6 | ||||||||
| weekly | |||||||||||
| Insulin-like growth factor I (IGF-I) | Serum | 36 | Acromegalic | Not specified | 1 | 8.1 | - | 3.9 | - | 10.8 | Mediagnost E20 IGF-I ELISA. NB only one cat but suggests difference to healthy cats |
| 5 | duplicate | - | 14.2 | ||||||||
| weekly | |||||||||||
| Free T4 | Serum | 54 | healthy | 9 x DSH | 10 | 10.4 | 13.4 | 4.9 | 1.2 | 33.8 | Equilibrium dialysis |
| Equilibrium dialysis | 1 x DLH | 6 | duplicate | Intermediate | 44.5 | Normality assumptions met. REML used for analyses. | |||||
| weekly | |||||||||||
| Free T4 | Serum | 69 | healthy | 10 x DSH | 15 | 18.2 | 7.1 | 9.0 | 0.3 | 56.3 | Equilibrium dialysis |
| Equilibrium dialysis | 5 x DLH | 7 | (16.4-19.9) | (6.5-7.8) | (8.2-9.9) | Low | 74.1 | Normality assumptions met. REML used for analyses. | |||
| 8-weekly | duplicate | ||||||||||
| Free T4 | Serum | 61 | healthy | 7 x DSH | 11 | 14.9 | 31.8 | 10.8 | 0.6 | 51 | Immulite 1000, 6 weeks (n=4),5 weeks (n=6),3 weeks (n=1),Checked for normal distribution. REML used |
| Immulite | 2 x DLH | ||||||||||
| 1x Devon Rex | 3 - 6 | duplicate | Low | 67.1 | |||||||
| 1x Persian X | weekly | ||||||||||
| Total T3 | Serum | 54 | healthy | 9 x DSH | 10 | 9.6 | 22.4 | 7.5 | 1.8 | 33.8 | Immulite 2000 |
| Chemiluminescent | 1 x DLH | 6 | QCM | High | 44.5 | Not enough volume for duplicate analyses. All results in lower half of population reference interval. REML used for analyses. | |||||
| weekly | |||||||||||
| Total T4 | Serum | 38 | healthy | 5 x DSH, | 7 | 11.4 | 20 | 3.8 | 1.7 | 33.3 | Abbot Architect c4000 |
| Immulite | 1x Balinese | 5 | duplicate | High | 43.8 | normal distribution by residuals histogram and QQ plots. | |||||
| 1x Bengal | weekly | ||||||||||
| Total T4 | Serum | 38 | healthy | 5 x DSH, | 7 | 11.4 | 20 | 3.8 | 1.7 | 33.3 | Abbot Architect c4000 |
| Immulite | 1x Balinese | 5 | duplicate | High | 43.8 | normal distribution by residuals histogram and QQ plots. | |||||
| 1x Bengal | weekly | ||||||||||
| Total T4 | Serum | 54 | healthy | 9 x DSH | 10 | 12.7 | 9.9 | 5.1 | 1.1 | 30.9 | Radio immuno assay. |
| Radio Immuno Assay | 1 x DLH | 6 | duplicate | Intermediate | 40.6 | Normality assumptions met. REML used for analyses. | |||||
| weekly | |||||||||||
| Total T4 | Serum | 69 | healthy | 10 x DSH | 15 | 13.2 | 8.3 | 7.1 | 0.6 | 41.5 | Vet Total RIA kit. |
| Radio Immuno Assay | 5 x DLH | 7 | (12.0-14.5) | (7.6-9.2) | (6.4-7.8) | Low | 54.7 | Normality assumptions met. REML used for analyses. | |||
| 8-weekly | duplicate | ||||||||||
| Total T4 | Serum | 61 | healthy | 7 x DSH | 11 | 11.6 | 12.7 | 4.2 | 1 | 34.1 | Immulite 1000 |
| Immulite | 2 x DLH | 6 weeks (n=4),5 weeks (n=6),3 weeks (n=1) | |||||||||
| 1x Devon Rex | 3 - 6 | duplicate | Intermediate | 44.9 | Checked for normal distribution. REML used | ||||||
| 1x Persian X | weekly | ||||||||||
| Total T4 | Serum | 69 | healthy | 10 x DSH | 15 | 15 | 13.5 | 5.7 | 0.8 | 44.5 | DRI assay, Microgenics |
| Enzyme Immuno Assay | 5 x DLH | 7 | (13.6-16.5) | (12.3-14.9) | (5.2-6.3) | Intermediate | 58.5 | Normality assumptions met. REML used for analyses. | |||
| 8-weekly | duplicate | ||||||||||
| TSH | Serum | 54 | healthy | 9 x DSH | 10 | 38.1 | 70.9 | 13.7 | 1.8 | 64.9 294.7 | Immulite 2000 |
| Immulite (Canine) | 1 x DLH | 6 | QCM | High | Not enough volume for duplicate analyses. All results in lower half of population reference interval. Results <0.03 ng/mL assigned as 0.02 ng/mL. Skewed distribution so RCV varies for decreases and increases | ||||||
| weekly | 84.4 387.9 | REML used for analyses. | |||||||||
| TSH | Serum | 61 | healthy | 7 x DSH | 11 | 32.3 | 28.7 | 3.7 | 1.1 | 90.1 | Immulite 1000 |
| Immulite (Canine) | 2 x DLH | 6 weeks (n=4),5 weeks (n=6),3 weeks (n=1). Results <0.03 ng/mL (8/56) assigned as 0.15 ng/mL | |||||||||
| 1x Devon Rex | 3 - 6 | duplicate | Intermediate | 118.6 | Checked for normal distribution. REML used | ||||||
| 1x Persian X | weekly | ||||||||||
| TSH | Serum | 69 | healthy | 10 x DSH | 15 | 30.8 | 52.2 | 6.1 | 1.7 | 51.2 195.2 | Immulite 2000xpi |
| Immulite (Canine) | 5 x DLH | 7 | (27.1-38.1) | (34.2-89.6) | (5.2-7.1) | values below detectable limit (<0.03ng/mL) excluded, log transformation for normality, REML, RCV varies for increasing or decreasing values | |||||
| 8-weekly | duplicate | High |
Urine
| Measurand | Sample Type | Reference | Health Status | Breed(s) | Subjects (n) Samples Frequency | CVI (%) | CVG (%) | CVA (%) Source | II | RCV (95%) RCV (99%) | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Specific Gravity (USG) | Urine | 70 | Healthy | not stated | 15 | 15.5 | 15.3 | 0.4 | 1.0 | 43.0 | MASTER-SUR/NM (Atago) handheld refractometer, visual assessment normality, REML |
| 7 | duplicate | Intermediate | 56.6 | ||||||||
| weekly | |||||||||||
| Protein | Urine | 70 | Healthy | not stated | 15 | 34.3 | 23.3 | 3.0 | 0.7 | 95.4 | Pyrogallol red technique (analyser not specified),visual assessment normality, REML |
| 7 | duplicate | Intermediate | 125.6 | ||||||||
| weekly | |||||||||||
| Creatinine | Urine | 70 | Healthy | not stated | 15 | 26.5 | 24.6 | 2.9 | 0.9 | 73.9 | Jaffe method (analyser not specified),visual assessment normality, REML |
| 7 | duplicate | Intermediate | 97.3 | ||||||||
| weekly | |||||||||||
| Protein:Creatinine ratio (UPC) | Urine | 70 | Healthy | not stated | 15 | 34.8 | 27.7 | 3.2 | 0.8 | 96.9 | ratio from above, , visual assessment normality, REML |
| 7 | duplicate | Intermediate | 127.5 | ||||||||
| weekly |
